Table of Contents
Common Questions
Chat with CodyMD
Cody's Chat with Patient
Cody's AI Summary
Top 3 AI Diagnosis List
Review by Dr Albert DiPiero
Dr. DiPiero Video Guide to this Case Study
Resource Center
Testimonials
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Case Study
Meet your host

Albert DiPiero, MD MPH FACP
I am a co-founder and the Chief Medical Officer at CodyMD and your host for this edition of Cody Grand Rounds. I have been a practicing physician and faculty member at medical schools for over 26 years.
About The AI Doctor Case Study
CodyMD is a partnership between Human Doctors and AI Doctors. Cody is an AI Doctor who helps thousands of people every day. At each Cody Grand Rounds, I select a real case and review it with Cody, the AI Doctor.
Each case is based on a real patient but has been modified to maintain privacy and to emphasize certain teaching points.
Common Questions
What are common symptoms of menopause?
Can diabetes affect symptoms during menopause?
What is the role of AI in diagnosing menopause?
Is there a link between menopause and sleep disturbances?
What symptoms can indicate hyperthyroidism?
How can AI help in managing mood changes?
What should be monitored if experiencing low blood sugar symptoms?
Chat with CodyMD
Click the button below to initiate a conversation with CodyMD, your AI Doctor.
Cody's Chat with Patient
Below is a conversation transcript between the patient and our AI Doctor CodyMd.

Cody, the AI Doctor
Hello, it's nice to meet you. I understand you’ve been experiencing flushing and hot flashes. Is that right?
Patient
Yes, that's correct. It's been happening on and off for over two years now.

Cody, the AI Doctor
I appreciate you sharing that with me. I know you’ve seen doctors before but haven’t felt listened to. Let’s dive into it and see if we can figure out what's going on. When did you first start noticing these symptoms?
Patient
It started sometime over two years ago. At first, they were occasional, but now I get them several times a week.

Cody, the AI Doctor
Got it. Have you also noticed any changes in your menstrual cycles over the past few years?
Patient
Actually, I haven’t had a period in about three years now.

Cody, the AI Doctor
That's helpful to know. Discontinuation of periods can sometimes correlate with certain conditions. Besides the flushing and hot flashes, have you experienced any other symptoms like trouble sleeping or mood changes?
Patient
Yes, I’ve had trouble sleeping. Some nights I wake up sweating, and I’ve been feeling more irritable lately, which isn’t like me.

Cody, the AI Doctor
I’m sorry to hear that. It can be difficult dealing with all those changes. Let me ask, with your diabetes, have you had any episodes of low blood sugar, especially around the times you feel flushed?
Patient
Now that you mention it, there were a few times I felt a bit shaky and thought it might be my sugar levels dropping, but I didn’t check.

Cody, the AI Doctor
That's important information. Low blood sugar can sometimes cause symptoms like you’re describing. Are there any symptoms that seem to happen with eating or physical activities?
Patient
Not really with eating, but sometimes after being active, like a walk, I get a bit flushed.

Cody, the AI Doctor
Understood. Besides the flushing and hot flashes, have you noticed any weight changes, or issues like a racing heart, or feeling unusually nervous?
Patient
I haven’t put on much weight, but I did feel my heart racing a few times. It was strange and felt a bit unsettling.

Cody, the AI Doctor
I see, and have there been any instances where you've had infections or fevers alongside these symptoms?
Patient
No, no infections or fevers that I remember.

Cody, the AI Doctor
Thanks for clarifying. Given everything you’ve shared, I have a clearer picture now. Let’s walk through what might be happening.
Cody's AI Summary
- 55-year-old woman with symptoms of flushing and hot flashes over two years, with an absence of menstrual periods for about three years.
- Additionally, she experiences trouble sleeping, occasional irritability, and a racing heart.
- She is diabetic, managed on semaglutide, and has hypertension controlled with lisinopril.
- She reports suspected low blood sugar episodes.
- No infections or fevers have been reported.
Top 3 AI Diagnosis List
Based on the information and conversations with Cody, we have prepared a top 3 AI Diagnosis List.
1. Menopause (70 % probability)
The cessation of periods, hot flashes, and sleep disturbances align strongly with menopausal symptoms. Hormonal changes in menopause often cause these experiences.
2. Hyperthyroidism (20 % probability)
Although less likely, symptoms like palpitations, potential weight change, and nervousness can suggest overactive thyroid activity, affecting metabolism.
3. Diabetes-related low blood sugar or medication side effects (10% probability)
Occasional shakiness, especially if not eating properly around medication times, might cause similar symptoms.
Review by Dr Albert DiPiero

Dr. Albert DiPiero
The patient presents with a history of several years of hot flashes, irregular sleep, and irritability. Here’s a detailed analysis of the top three AI-generated diagnoses:
1. Menopause (80 % probability)
Menopause remains the leading diagnosis with a high probability, given her age and the fact that she has not had a menstrual period in three years. These points, combined with the vasomotor symptoms of hot flashes and night sweats, strongly suggest menopause as the principal diagnosis.
2. Hyperthyroidism (10 % probability)
Hyperthyroidism is a differential consideration due to intermittent racing heart and potential nervousness. However, other typical indicators like significant weight loss or tremors are not apparent, making its probability lower at 10%.
3. Diabetes-related low blood sugar or medication side effects (5% probability)
Diabetes management should also be evaluated. The usage of semaglutide and correlation of symptoms with possible low blood sugar episodes introduce diabetes-related causes such as medication timing and dietary habits as contributory factors. The coinciding symptoms could indeed be influenced by fluctuations in blood sugar levels.
4. Other considerations:
Anxiety Disorders (5% probability): Intermittent racing heart and irritability might parallel anxiety episodes, unrelated to menopause-induced mood changes. Pheochromocytoma (5% probability): This rare tumor could cause episodic hypertension spikes and flushing, but typical associated symptoms are insufficiently present here.
Next Steps for Evaluation
Next Steps should include hormonal profiling to confirm menopause, a thyroid function test, and comprehensive glucose monitoring. Hormonal profiling involves a series of laboratory tests to measure specific hormone levels that can help confirm menopause and rule out other potential conditions. For this patient, the recommended hormonal tests would typically include:
Follicle-Stimulating Hormone (FSH): Elevated levels of FSH are indicative of menopause, as the ovaries produce less estrogen and the pituitary gland increases production of FSH.
Estradiol: This is a form of estrogen, and low levels typically can confirm menopausal status, aligning with reduced ovarian function.
Luteinizing Hormone (LH): Similar to FSH, an increase in LH levels can support a diagnosis of menopause.
Thyroid Function Tests: Evaluating both TSH and free T4 can help rule out thyroid abnormalities, which might be causing or exacerbating symptoms.
These hormonal tests together will provide a comprehensive profile that can differentiate between menopausal transition and other hormonal imbalances, such as thyroid dysfunction or other endocrine disorders. The results will guide treatment decisions and management strategies accordingly.
Additionally, detailed lifestyle and dietary analysis can ensure diabetes management is contributing effectively to symptom control.
Treatment Modalities
Hormonal treatments: hormone Replacement Therapy (HRT) is a primary treatment option for managing menopausal symptoms, such as hot flashes, night sweats, mood swings, and vaginal dryness. It works by replenishing the hormones that the body no longer produces post-menopause by administering estrogen or a combination of estrogen and progestin.
Non-hormonal treatments such as gabapentin or SSRIs, helpful for vasomotor symptoms.
In addition to conventional medical treatments for menopause, many women explore herbal and alternative remedies to alleviate symptoms. These remedies are popular for their perceived natural approach and fewer side effects, though scientific evidence varies. Some frequently considered options include:
Phytoestrogens: Found in soybeans, flaxseeds, and whole grains, phytoestrogens are plant-derived compounds structurally similar to estrogen and may help alleviate hot flashes and night sweats by mimicking estrogen's effects in the body.
Black Cohosh: This herb is commonly used to reduce hot flashes and other menopausal symptoms. While some studies suggest its effectiveness, results are mixed, and long-term safety is not well-established.
Red Clover: Similar to phytoestrogens, red clover contains isoflavones that may provide relief from hot flashes and contribute to bone health.
Evening Primrose Oil: Often used for hot flashes, its effectiveness is still debated, though some women find it helpful in managing symptoms.
Lifestyle Practices: Stress reduction techniques such as yoga, tai chi, acupuncture, and meditation can improve overall well-being and potentially reduce menopausal symptoms like irritability and insomnia.
While these remedies can offer relief for some, their efficacy and safety are not universally established, and they should be used with caution.
Blood sugar regulation strategies including dietary adjustments and perhaps revisiting diabetes management plans and medication regimens.
Conclusion
In summary, while menopausal symptom treatment should remain a focal point, comorbidities such as diabetes require careful management to mitigate exacerbating factors. A multi-faceted treatment plan personalized to the patient's comprehensive symptoms can ensure holistic care.
Dr. DiPiero Video Guide to this Case Study
Resource Center
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